2014

1Fonseca-Ornelas L, Eisbach SE, Paulat M, Giller K, Fernández CO, Outeiro TF, Becker S, Zweckstetter M.
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.
Nat Commun. 2014 Dec 19;5:5857. doi: 10.1038/ncomms6857. PubMed

 

 

 

1Lopes da Fonseca T, Outeiro TF.
ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.
Exp Neurobiol. 2014 Dec;23(4):314-23. doi: 10.5607/en.2014.23.4.314. PubMed

 

 

 

1Poças GM, Branco Dos Santos J, Herrera F, Outeiro TF, Domingos PM.
α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila.
Hum Mol Genet. 2014 Dec 1. PubMed

 

 

 

1Macedo D, Tavares L, McDougall GJ, Miranda HV, Stewart D, Ferreira RB, Tenreiro S, Outeiro TF, Santos CN.
(Poly)phenols protect from alpha-synuclein toxicity by reducing oxidative stress and promoting autophagy.
Hum Mol Genet. 2014 Nov 28. PubMed

 

 

 

1Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B,  Rizzoli SO, Braus GH, Danzer KM, Outeiro TF.
Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation.
PLoS Genet. 2014 Nov 13. PubMed

 

 

 

1Poehler AM, Xiang W, Spitzer P, May V, Meixner H, Rockenstein E, Chutna O, Outeiro T, Winkler J, Masliah E, Klucken J.
Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment.
Autophagy. 2014 Oct 30:e36436. PubMed

 

 

 

1Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F.
Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour.
Hum Mol Genet. 2014 Oct 9. PubMed

 

 

 

1Shahpasandzadeh H, Popova B, Kleinknecht A, Fraser PE, Outeiro TF, Braus GH.
Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions.
J Biol Chem. 2014 Nov 7. PubMed

 

 

 

1Fernandes JT, Tenreiro S, Gameiro A, Chu V, Outeiro TF, Conde JP.
Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator.
Lab Chip. 2014 Aug 28. PubMed

 

 

 

1Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF.
Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Hum Mol Genet. 2014 Aug 20.pii: ddu421. PubMed

 

 

 

1Perfeito R, Lázaro DF, Outeiro TF, Rego AC.
Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells.
Mol Cell Neurosci. 2014 Aug 7;62C:51-59. doi: 10.1016/j.mcn.2014.08.002. PubMed

 

 

 

1Chutna O, Gonçalves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF.
The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
Hum Mol Genet. 2014 Aug 4. pii: ddu391. PubMed

 

 

 

1Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF
DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease.
Cell Death Dis. 2014 Jul 24;5:e1350. doi: 10.1038/cddis.2014.307. PubMed

 

 

 

1Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő EM, Guerreiro P, Lazaro D, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M.
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Neurobiol Dis. 2014 Jun 28. pii: S0969-9961(14)00182-X. PubMed

 

 

 

1Tenreiro S, Eckermann K, Outeiro TF.
Protein phosphorylation in neurodegeneration: friend or foe?
Front Mol Neurosci. 2014 May 13;7:42. eCollection 2014. PubMed

 

 

 

1Tenreiro S, Reimão-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhães F, Gomes A, Santos CN, Kaganovich D, Outeiro TF.
Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson’s disease.
PLoS Genet. 2014 May. PubMed

 

 

 

1Miller-Fleming L1, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF.
Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase.
PNAS 2014 April. PubMed

 

 

 

1Rodrigues TM1, Jerónimo-Santos A, Outeiro TF, Sebastião AM, Diógenes MJ.
Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson’s disease
Drugs & Aging. 2014 April. PubMed

 

 

 

1Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; REGISTRY investigators of the European Huntington’s Disease Network.
β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington’s Disease.
J Huntingtons Dis. 2014 Mar. PubMed

 

 

 

1Vittori A, Breda C, Repici M, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; the REGISTRY investigators of the European Huntington’s Disease Network.
Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington’s disease.
Hum Mol Genet. 2014 Feb. PubMed