2015

1Oliveira LM, Falomir-Lockhart LJ, Botelho MG, Lin KH, Wales P, Koch JC, Gerhardt E, Taschenberger H, Outeiro TF, Lingor P, Schüle B, Arndt-Jovin DJ, Jovin TM.
Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson’s patient-derived induced pluripotent stem cells.
Cell Death Dis. 2015 Nov 26;6:e1994. doi: 10.1038/cddis.2015.318.PubMed

 

 

 

1Gomes P, Outeiro TF, Cavadas C.
Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism.
Trends Pharmacol Sci. 2015 Nov;36(11). PubMed

 

 

 

1Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Gonçalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV.
Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity.
Cereb Cortex. 2015 Nov 2. pii: bhv268. PubMed

 

 

 

1Vreja IC, Nikić I, Göttfert F, Bates M, Kröhnert K, Outeiro TF, Hell SW, Lemke EA, Rizzoli SO.
Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies.
ACS Nano. 2015 Oct 28. PubMed

 

 

 

1Moree B, Yin G, Lázaro DF, Munari F, Strohäker T, Giller K, Becker S, Outeiro TF, Zweckstetter M, Salafsky J.
Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce its Aggregation in Cells.
J Biol Chem. 2015 Sep 22. pii: jbc.M114.636027. PubMed

 

 

 

1Dučić T, Carboni E, Lai B, Chen S, Michalke B, Lázaro DF, Outeiro TF, Bähr M, Barski E, Lingor P.
Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium.
ACS Chem Neurosci. 2015 Aug 25. [Epub ahead of print]. PubMed

 

 

 

1Krey L, Lühder F, Kusch K, Czech-Zechmeister B, Könnecke B, Outeiro TF, Trendelenburg G.
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
J Cereb Blood Flow Metab. 2015 Jul 29. doi: 10.1038/jcbfm.2015.178. [Epub ahead of print]. PubMed

 

 

 

1Villar-Piqué A, da Fonseca TL, Outeiro TF.
Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.
J Neurochem. 2015 Jul 18. doi: 10.1111/jnc.13249. [Epub ahead of print]. PubMed

 

 

 

1Guerreiro PS, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro TF, Eckermann K.
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
Mol Neurobiol. 2015 May 27. PubMed

 

 

 

1Fonseca TL, Villar-Piqué A, Outeiro TF.
The Interplay between Alpha-Synuclein Clearance and Spreading.
Biomolecules. 2015 Apr 14;5(2):435-471. PubMed

 

 

 

1Nunes P, Morais GR, Palma E, Silva F, Oliveira MC, Ferreira VF, Mendes F, Gano L, Vicente Miranda H, Outeiro TF, Santos I, Paulo A.
Isostructural Re(i)/(99m)Tc(i) tricarbonyl complexes for cancer theranostics.
Org Biomol Chem. 2015 Apr 29;13(18):5182-94. doi: 10.1039/c5ob00124b. PubMed

 

 

 

1Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA
Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo.
J Biol Chem. 2015 Apr 10;290(15):9412-27. doi: 10.1074/jbc.M114.610774. PubMed

 

 

 

1Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson’s disease but not amyotrophic lateral sclerosis and cerebral ischemia.
PLoS One. 2015 Jan 21;10(1):e0116919. doi: 10.1371/journal.pone.0116919. eCollection 2015. PubMed

 

 

 

1Poças GM, Branco-Santos J, Herrera F, Outeiro TF, Domingos PM.
α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila.
Hum Mol Genet. 2015 Apr 1;24(7):1898-907. doi: 10.1093/hmg/ddu606. Epub 2014 Dec 1. PubMed

 

 

 

1Macedo D, Tavares L, McDougall GJ, Vicente Miranda H, Stewart D, Ferreira RB, Tenreiro S, Outeiro TF, Santos CN.
(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy.
Hum Mol Genet. 2015 Mar 15;24(6):1717-32. doi: 10.1093/hmg/ddu585. PubMed