2016

1 Lázaro DF, Dias MC, Carija A, Navarro S, Madaleno CS, Tenreiro S, Ventura S, Outeiro TF.
The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. December 9, 2016.PubMed

 

 

 

1 Vicente Miranda, Gomes M, Branco-Santos, Breda C, Lázaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF.
Glycation potentiates neurodegeneration in models of Huntington’s disease. November 18, 2016.PubMed

 

 

 

1 Fernandes JT, Chutna O, Chu V, Conde JP, Outeiro TF.
A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson’s Disease and Other Synucleinopathies. November 15, 2016..PubMed

 

 

 

1 Villar-Piqué A, Lopes da Fonseca T, Sant’Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF.
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. October 18, 2016.PubMed

 

 

 

1 Tenreiro S, Macedo D, Marijanovic Z, Outeiro TF.
Analysis of Protein Oligomeric Species by Sucrose Gradients. September 10, 2016.PubMed

 

 

 

1 Lázaro DF, Dias M, Carija A, Navarro S, Madaleno CS, Tenreiro S, Ventura S, Outeiro TF.
The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. Acta Neuropathologica Communications. 2016 Dez.PubMed

 

 

 

1 Vicente Miranda H, Gomes M, Branco-Santos J, Breda C, Lázaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF.
Glycation potentiates neurodegeneration in models of Huntington’s disease. Sci Rep. 2016 Nov.PubMed

 

 

 

1 Kleinknecht A, Popova B, Lázaro DF, Pinho R, Valerius O, Outeiro TF, Braus GH.
C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson’s Disease. PLoS Genet. 2016 Jun.PubMed

 

 

 

1 Maria Angeliki S. Pavlou, Raquel Pinho, Isabel Paiva, Tiago Fleming Outeiro.
The yin and yang of alpha-synuclein-associated epigenetics in Parkinson’s disease.
Brain. 2016 Aug 31.PubMed pii: aww227

 

 

 

1 Guerreiro PS, Coelho JE, Sousa-Lima I, Macedo P, Lopes LV, Outeiro TF, Pais TF.
Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits
and Affects Metabolic Pathways.
Neuromolecular Med. 2016 Aug 17. PubMed PMID: 27535567.

 

 

 

1 Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M,Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV.
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Sci Rep. 2016 Aug 11. PubMed PMID: 27510168; PubMed Central PMCID: PMC4980603.

 

 

 

1 Letra-Vilela R, Sánchez-Sánchez AM, Rocha AM, Martin V, Branco-Santos J,Puente-Moncada N, Santa-Marta M, Outeiro TF, Antolín I, Rodriguez C, Herrera F.
Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin. Mol Cell Endocrinol. 2016 Oct 15;434:238-49. doi: 10.1016/j.mce.2016.07.012. Epub 2016 Jul 9. PubMed PMID:27402602.

 

 

 

1 Kleinknecht A, Popova B, Lázaro DF, Pinho R, Valerius O, Outeiro TF, Braus GH.
C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson’s Disease.
PLoS Genet.2016 Jun 24;12(6):e1006098. doi: 10.1371/journal.pgen.1006098. eCollection 2016 Jun. PubMed PMID: 27341336; PubMed Central PMCID: PMC4920419.

 

 

 

1 Gonçalves SA, Outeiro TF.
Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease.
Small GTPases. 2016 Jun 17:1-7.PubMed PMID: 27314512.

 

 

 

1 Lopes da Fonseca T, Pinho R, Outeiro TF.
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.
Hum Mol Genet. 2016 Jun 8.pii: ddw147.PubMed PMID: 27282395.

 

 

 

1 Pardo J, Uriarte M, Cónsole GM, Reggiani PC, Outeiro TF, Morel GR, Goya RG.
Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis,astrocyte branching and improves spatial memory in female aging rats.
Eur J Neurosci. 2016 Aug;44(4):2120-8. doi: 10.1111/ejn.13278. Epub 2016 Jun 8. PubMed PMID: 27188415.

 

 

 

1 Gonçalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, Barral DC, Ferreira Moita L, Outeiro TF.
shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.
PLoS Genet. 2016 Apr 28;12(4):e1005995. doi:10.1371/journal.pgen.1005995. eCollection 2016 Apr. Erratum in: PLoS Genet. 2016 Jun;12(6):e1006148. PubMed PMID: 27123591; PubMed Central PMCID: PMC4849646.

 

 

 

1 Tatenhorst L, Eckermann K, Dambeck V, Fonseca-Ornelas L, Walle H, Lopes da Fonseca T, Koch JC, Becker S, Tönges L, Bähr M, Outeiro TF, Zweckstetter M, Lingor P.
Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease.
Acta Neuropathol Commun. 2016 Apr 22;4:39. doi:10.1186/s40478-016-0310-y. PubMed PMID: 27101974; PubMed Central PMCID:PMC4840958.

 

 

 

1Gustafsson G, Eriksson F, Möller C, da Fonseca TL, Outeiro TF, Lannfelt L,Bergström J, Ingelsson M.
Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors.
Cell Mol Neurobiol. 2016 Mar 10.PubMed PMID: 26961542.

 

 

 

1Vicente Miranda H, El-Agnaf OM, Outeiro TF
Glycation in Parkinson’s disease and Alzheimer’s disease
Mov Disord. 2016 Jun;31(6):782-90. doi: 10.1002/mds.26566. Epub 2016 Mar 4. Review. PubMed PMID: 26946341.

 

 

 

1Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S.
αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington’s disease..
Hum Mol Genet. 2016 Feb 26. pii: ddw028. PubMed

 

 

 

1Tenreiro S, Rosado-Ramos R, Gerhardt E, Favretto F, Magalhães F,
Popova B, Becker S, Zweckstetter M, Braus GH, Outeiro TF.
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.
Hum Mol Genet. 2016 Jan 15;25(2):275-90. doi: 10.1093/hmg/ddv470. Epub 2015 Nov
18.PubMed

 

 

 

1

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ,…, Outeiro TF, …Zong WX, Zorzano A.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd
edition).

Autophagy. 2016 Jan 2;12(1):1-222.PubMed