The ultimate aim of our research on the pathogenesis of neurodegenerative diseases is to develop treatments that interfere with its deleterious cascade. This would add to the treatments that are available today, namely dopamimetics and deep brain stimulation, and also enhance the prognosis and the quality of life of patients. We and others have identified protein aggregates, oxidative stress and mitochondrial dysfunction, excitotoxicity and apoptosis as important mediators of neuronal death, specifically in Parkinson’s disease