The Department of Neurodegeneration and Restorative Research studies the biology and experimental therapies of neurodegenerative diseases.
Our research interests are focused on the understanding of the molecular mechanisms which lead to neurodegeneration in diseases such as Parkinson’s, Huntington’s, or Alzheimer’s disease. These diseases are intimately associated with protein misfolding and aggregation in specific regions of the brain.
Because the molecular pathways involved in protein homeostasis are highly conserved, we employ a wide variety of model organisms, from the simple but powerful budding yeast to mammalian cell culture and mice, to study the origin of the problems.
Our ultimate goals are to develop novel therapeutic approaches for these and other related disorders. We are working closely together with clinicians in order to accelerate drug discovery efforts, translating basic research into clinical applications that will improve the lives of patients.
- Protein misfolding, oligomerization and aggregation
- Yeast models for Parkinson’s and Huntington’s disease
- Modulators of protein aggregation and toxicity
- Microscopy-based methods for investigating the molecular nature of the toxic proteinaceous species in Parkinson’s disease
- In vivo imaging using multi-photon microscopy
- Development of novel therapeutic approaches for neurodegenerative disease