Exact mechanisms of heat shock–induced lifespan extension, although documented across species, are still not well understood. Here, we show […]
Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
Parkinson’s disease (PD) is a common neurodegenerative condition known for typical motor symptoms associated with the loss of dopaminergic […]
A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria.
With the hope that disease-modifying treatments […]
Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments.
Advanced glycation end products (AGEs) arise from the Maillard reaction between dicarbonyls and proteins, nucleic acids, or specific lipids. […]
Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism.
As the physical barrier between the cell and the outside environment, the plasma membrane is well-positioned to be the […]
Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson’s […]
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously […]
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity
Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant […]
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
α-Synuclein misfolding and aggregation is a hallmark in Parkinson’s disease and in several other neurodegenerative diseases known as synucleinopathies. […]
α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B
Synucleinopathies, such as Parkinson’s disease and dementia with Lewy bodies, are neurodegenerative disorders that are characterized by the accumulation […]