Promises, hopes, and dreams in Parkinson’s disease research
Since James Parkinson first described his eponymous disease, our knowledge of its pathophysiology has grown enormously. However, in […]
Lead as an environmental toxicant in models of synucleinopathies
Lead, a toxic heavy metal, is prevalent in various industrial applications, contributing to environmental contamination and significant health […]
A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features
Parkinson’s disease (PD) affects millions of people worldwide, but only 5–10% of patients suffer from a monogenic forms […]
Exact mechanisms of heat shock–induced lifespan extension, although documented across species, are still not well understood. Here, we show […]
Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
Parkinson’s disease (PD) is a common neurodegenerative condition known for typical motor symptoms associated with the loss of dopaminergic […]
A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria.
With the hope that disease-modifying treatments […]
Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments.
Advanced glycation end products (AGEs) arise from the Maillard reaction between dicarbonyls and proteins, nucleic acids, or specific lipids. […]
Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism.
As the physical barrier between the cell and the outside environment, the plasma membrane is well-positioned to be the […]
Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson’s […]
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously […]